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    Preclinical Therapeutics Mouse Modeling Shared Resource

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    Please remember to cite the Shared Resources!

    Research reported in this publication was supported by The Ohio State University Comprehensive Cancer Center and the National Institutes of Health under grant number P30 CA016058.

    We thank the XX Shared Resource at The Ohio State University Comprehensive Cancer Center, Columbus, OH for (XX)

    About Us:(back to top)

    The Preclinical Therapeutics Mouse Modeling Shared Resource (PTMMSR) supports investigators to generate cost-effective and reproducible in vivo proof-of-concept preclinical data through knowledge, technical expertise, and centralized resources for mouse models and instrumentation.

    940 Biomedical Research Tower
    460 W. 12th Ave.
    Columbus, OH 43210

    Phone: 614-293-1675

    Meet the Team:(back to top)

    Reena Shakya, PhD - Director reena.shakya@osumc.edu

    Dr. Shakya is an expert in mouse genetics with extensive knowledge and experience in mouse models of cancer. She earned her doctoral degree in genetics and developmental biology at Columbia University, New York where she trained with Dr. Frank Costantini who is among the pioneers in mouse transgenics. She completed postdoctoral fellowship at Columbia University with Dr. Thomas Ludwig. During her postdoctoral training, Dr. Shakya developed several mouse models of cancer to study breast and pancreatic cancers and performed therapeutic studies with them.

    Ryejung Na, PhD, received her doctorate in microbiology from Korea followed by a postdoctoral training in oncology at the University of Utah. She is experienced with in vitro assay development and preclinical mouse studies.

     

    Available Services: (back to top)

    • Breeding programs for GEMM models of cancer
    • Breeding programs for immune-compromised mouse strains (athymic nude and NSG (NOD-SCID-IL2γR))
    • Xenografting and allografting of tissues and cells
    • Administration of therapeutics via various routes (e.g., intraperitoneal, intravenous, oral gavage, subcutaneous, intramuscular)
    • Monitoring of animals post-administration of therapeutics (e.g., body weight and score)
    • Necropsy including tumor and other tissue harvest for downstream applications
    • Tumor monitoring by standard caliper measurement or using other imaging modalities (the latter is conducted in collaboration with Small Animal Imaging Shared Resource, SAISR)
    • Consultation and letter-of-support for grant applications are provided at no charge

    Click here for full list of services and fees

    Please remember to cite the Shared Resources!

    Research reported in this publication was supported by The Ohio State University Comprehensive Cancer Center and the National Institutes of Health under grant number P30 CA016058.

    We thank the XX Shared Resource at The Ohio State University Comprehensive Cancer Center, Columbus, OH for (XX)

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