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• Meet the Team
• Available Services
• Equipment Reservations (CEMAS)
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Please remember to cite the Shared Resources!

Research reported in this publication was supported by The Ohio State University Comprehensive Cancer Center and the National Institutes of Health under grant number P30 CA016058.

We thank the XX Shared Resource at The Ohio State University Comprehensive Cancer Center, Columbus, OH for (XX)

About Us:(back to top)

The MSR is a full-service resource — from extensive sample preparation laboratories to image-processing tools — allowing OSUCCC investigators to carry out their entire microscopy and analysis program at Ohio State.

Through the MSR, OSUCCC investigators gain access to one of the largest concentrations of light, electron and ion beam microscopy instruments in any North American institution. The MSR pools resources to provide timely, high-quality services that support OSUCCC investigators with instrumentation, expertise and training on various microscopy approaches. These approaches include detecting viruses; leveraging advancements in cryo-electron microscopy (cryo-EM) to visualize the structure of cancer proteins or biomolecules at near-atomic resolution; the examination of nanostructures for drug delivery with transmission electron microscopy (TEM); conducting live cell imaging in response to different treatments; and reconstructing tumor models in three dimensions using confocal microscopy (CM), super resolution structured illumination microscopy (SIM), total internal reflection fluorescence (TIRF) microscopy and stochastic optical reconstruction microscopy (STORM). We also have the potential to follow dynamic events, such as the movement of immune cells in tumors of living animals, using multiphoton microscopy.

Consultation and support on subjects ranging from experimental design, troubleshooting and data analysis are available, as well as training tailored to OSUCCC investigators' needs on all microscope systems. Processing and analysis software for image presentation and publication is also readily available.

The MSR plays an essential role in allowing cancer investigators to translate fundamental studies of cancer biology into new treatments.

Campus Microscopy & Imaging Facility (CMIF)
Biomedical Research Tower, Room 245
Phone: 614-292-9786 Email: cmif@osu.edu

Center for Electron Microscopy and Analysis (CEMAS)
1305 Kinnear Rd
Suite 100
Phone:(614) 643-3110 Email: cemas@osu.edu 

Meet the Team (back to top)

Richard Fishel, PhD - Co- Director, CMIF rfishel@osu.edu

Dr. Fishel is a professor in the Department of Cancer Biology and Genetics at The Ohio State University, where he also serve as co-leader of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James. His research interests include DNA repair and genomic instability in cancer development, the biophysical chemistry of DNA repair as well as single-molecule imaging and tracking in vitro and in vivo.

David McComb, PhD - Co-Director, CEMAS mccomb.29@osu.edu

Dr. McCombs is Director of the Center for Electron Microscopy and Analysis (CEMAS), an Ohio Research Scholar and Professor of Materials Science and Engineering at The Ohio State University. A chemistry graduate from the University of Glasgow, David completed his PhD in Physics at the University of Cambridge. David is an expert in the development and application of electron energy-loss spectroscopy (EELS) as a sub-nanometer scale probe for chemistry, structure, and bonding. He has developed and implemented approaches to studying inorganic, organic, and molecular systems using electron microscopy techniques.

Jeffrey Tonniges, PhD - Interim Co- Director tonniges.1@osu.edu

Jeff joined the CMIF in 2020 and took over as interim director in 2024. He received a MS in physics from Creighton University, where he studied the photo- and biophysical properties of lipophilic dyes. He received his PhD in biophysics from the Ohio State University, where he studied the structure and function of collagen in numerous tissues. He has expertise in biological TEM, confocal, multiphoton, and second harmonic generation microscopy.

Stephanie Amici, PhD -- Microscopy Specialist (CMIF)

Brian Kemmenoe, BS – Senior Electron Microscopist (CMIF)

Binbin Deng, PhD – Senior Research Associate (CEMAS)

Yoshie Narui, PhD – Senior Cryo-EM Researcher (CEMAS)

Giovanna Grandinetti, PhD – Cryo-EM Researcher (CEMAS)

Sarah Mikula, BS – Laboratory Supervisor (CEMAS)

Available Services: (back to top)

• Live cell microscopy
• Confocal microscopy
• Multiphoton microscopy
• Structured illumination microscopy (SIM)
• Stochastic optical reconstruction microscopy (STORM)
• Total Internal Reflection Fluorescence (TIRF) microscopy
• Transmission electron microscopy (TEM)
• Scanning electron microscopy (SEM)
• Cryo electron microscopy
• Focused ion beam microscopy
• Image analysis
• Electron microscopy sample preparation

What do I need?

Follow the chart below or click here to determine which branch of MSR will fit your needs.

Click here for full list of services and fees

Equipment Reservations: (back to top)

Facility Online Manager (FOM)

Please remember to cite the Shared Resources!

Research reported in this publication was supported by The Ohio State University Comprehensive Cancer Center and the National Institutes of Health under grant number P30 CA016058.

We thank the XX Shared Resource at The Ohio State University Comprehensive Cancer Center, Columbus, OH for (XX)

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