Total Cancer Care (TCC)
Navigation Menu:
What is available from TCC at OSU?
- Biospecimens including frozen tissue (tumor and adjacent normal), plasma, serum, DNA, tissue from FFPE and some additional non-invasive specimens such as buccal swabs, stool, etc.). Note: not all patients have associated specimens.
- Clinical data (sources include EPIC, James Cancer Registry and other clinical platforms such as those for radiation oncology, radiology, digital pathology). Clinical data are provided as de-identified, coded limited or PHI depending upon the request. Note: PHI requires an additional IRB-approved protocol.
- Raw or processed genomic data and associated clinical data for OSU cases in the ORIEN Avatar project
- Opportunity to coordinate consent to other protocols to utilize specimens and data across both protocols.
- Consenting, procurement, processing, banking and distribution are funded by TCC. There is no charge to investigators.
- Letters of support for grants.
- How do I request TCC specimens or data?
- Use this link: https://go.osu.edu/osutcc
What is the process once I complete my request?
- A TCC project manager will review your request and follow-up with any questions/clarification needed.
- The TCC team will assess feasibility and determine if the TCC has the number of patients/specimens requested.
- The TCC Research Committee will review requests.
- Once approved by the research committee, the TCC team will begin fulfilling the request.
- Please note: frozen specimens come from the TCC Biorepository. FFPE material will come from Pathology Tissue Archive Services—requesting FFPE material will add time to fulfillment.
For additional information on Total Cancer Care, please contact Laura Monovich, MBA, TCC Operations Director (laura.monovich@osumc.edu)
TCC FAQ (back to top)
How do I request access to TCC specimens and data?
Please use the following link to make your request, https://go.osu.edu/osutcc
A how to make a request video is located here: https://osu.zoom.us/rec/share/vwg8AWF1JB0dddmEa4qMbw1VecK2l-cI9jwb8gPj4Bpw7rT0kE_FbYWBF0OWh402.Uifhwk86RmdJIIyp?startTime=1680200537000
What is available through TCC?
- Biospecimens (including but not limited to frozen tumor/normal tissue; plasma, serum, DNA, FFPE)
- Clinical data from the James Cancer Registry and Epic (the EMR)
- Research-grade genomic sequencing data – WES and RNA Seq (raw and processed) and a clinical dataset on a subset of TCC patients
- Letters of support for projects and grants
What is the cost associated with a TCC request?
There is no cost at this time.
Can clinical & molecular data requests be refreshed over time?
- Current IRB-approved studies can receive refreshed data.
- De-identified and coded limited data requests are not eligible for updates after 90 days per medical center clinical data policy.
What are the molecular data file types available?
RNA-Seq data files include (per sample):
- FASTq
- CRAM, CRAI
- Gene expression
- Isoform expression
- Fusion predictions (STAR fusion & Arriba)
- Fusion prediction pdf files
WES data files include (per sample):
- FASTq
- CRAM, CRAI – tumor and normal
- Recalibration table
- .g.vcf file
- VCF – tumor and normal
- Paired Mutect2 VCF
- Annotated somatic and tumor VCF (by Funcotator and Aster PoN)
- MSIsensor2 output (.tar compressed)
- Sequenza somatic CNV output
- Segments, seqz intermediate files
- Graphical CNV outputs at chromosome and genome levels
- Per gene CNV calls
- scarHRD per T/N pair
Can I have access to the processed files? Yes
Can I have access to the raw files? Yes
Once I receive the email from TCC that my molecular data is available, how long do I have to download it? 45 days
Can TCC analyze my molecular data request?
No, but we can connect with a bioinformatician if you are not already working with one.
Can TCC transfer my molecular data files to OSC?
No, that would be done by you/your lab.
How much storage space should I have for the molecular data?
That will depend upon the size of the request and type of data requested (e.g., processed vs. raw). The TCC team can advise.
I have submitted my data/specimen request. How long will it take for me to receive the specimens and/or data?
Timelines for completion of data/specimen requests varies based on the specifics of each request (number of patients, volume and types of data and specimens).
Factors that influence fulfillment time include:
- the number and types of specimens being requested,
- the number and of patients on whom data is being requested,
- investigator response time for questions and clarifications related to the request,
- the number of other TCC requests currently in the queue
- if FFPE material is being requested, that will have an impact on fulfillment time due to look-up time and dependency on pathology tissue archive services to retrieve the material.
A summary of the current stage of the process that your request is in can be found at [link to REDCap request summary]
A how to make a request video is located here: https://osu.zoom.us/rec/share/vwg8AWF1JB0dddmEa4qMbw1VecK2l-cI9jwb8gPj4Bpw7rT0kE_FbYWBF0OWh402.Uifhwk86RmdJIIyp?startTime=1680200537000
What are some tips to make my request go faster?
- Provide clear inclusion/exclusion criteria for the cases for your project. If you have an approved IRB protocol associated with the study and can provide patients that you know fulfill the requirements of the project at the time of submission, then the amount of time spent in the case-finding process can be significantly reduced.
- Respond to questions from TCC staff regarding the project in a timely manner. We are always happy to have a call if that is easier and more efficient.
- If you have a specific timeline by which you need data/specimens, provide that information as part of your request. TCC staff can estimate whether or not the timeline is practical based on previous experience.
- If there are specific guidelines for tissue requests (such as tissue for an external institution, etc.) provide those guidelines in the request.
- Many requests experience considerable delays waiting on completion of an MTA/DUA. It may be beneficial to have started the MTA before submitting a request to the TCC.
What kinds of data can I request from the TCC?
The TCC has access to many data points available from the Cancer Registry and Epic, the electronic medical record. The data provided are based on the request—there is not a “standard” dataset for TCC patients. Some data points are not discretely captured in the medical record; accordingly, these data may require a separate chart review on the investigator’s part.
There is a standard clinical dataset for ORIEN Avatar patients.
Can I request a letter of support?
Yes, please use the following link to make your request, https://go.osu.edu/osutcc. Please submit a request at least one week in advance and include a draft letter, the funding source, and the type of funding.