Biospecimen Services

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Total Cancer Care (TCC)
Tissue Procurement Services (TPS)
BSSR Biorepository
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Please remember to cite the Shared Resources!

Research reported in this publication was supported by The Ohio State University Comprehensive Cancer Center and the National Institutes of Health under grant number P30 CA016058.

We thank the XX Shared Resource at The Ohio State University Comprehensive Cancer Center, Columbus, OH for (XX)

The BSSR is comprised of three arms as described below:

Arm 1: Total Cancer Care (TCC) (back to top)

Daniel Stover, MD - TCC PI daniel.stover@osumc.edu

His research focus is clinical computational oncology – the application of computational approaches to leverage the immense available and potential data from tumor genomic profiling to improve outcomes for patients with cancer. The explosion of tumor genomic data rapidly advanced our understanding of cancer but requires new approaches to answer clinical questions. Specifically, we study resistance to therapy in breast and other cancers by integrating genomic data with patient features and outcomes. By studying patient samples, including on clinical trials, we seek to identify new mechanisms of drug resistance to standard agents as well as investigational agents such as immunotherapy. The ultimate goal of this work is to identify predictive markers for treatment response while identifying novel susceptibilities that allow us to overcome drug resistance.

TCC Operations Director: Laura Monovich, MBA

The first arm is a universal consenting and biobanking protocol, Total Cancer Care (TCC). Total Cancer Care® allows for the collection of blood and remnant tissue from surgical procedures. Eligibility includes patients 18 years of age and older, with and without cancer, who are seen at The James. Participating patients also consent to the use of their medical and genomic information. This lifetime consent allows for recontacting patients for an annual health status update if needed, and/or to notify them about opportunities to participate in clinical trials for which they are eligible. As of February, 2024, over 70,000 patients at the James have consented to participate.

Plasma, serum and DNA, along with snap frozen tissue, are stored for future research. The collected biospecimens are stored at the College of American Pathologists-accredited BSSR Biorepository located at The Ohio State University's Polaris Innovation Centre. Researchers may receive samples and data with subject identifiers with prior IRB-approval or de-identified and coded-limited data sets without additional prior IRB approvals.

TCC is the single protocol used by the Oncology Research Information Exchange Network (ORIEN), which was formed through a partnership between the OSUCCC – James and Moffitt Cancer Center in Tampa, Fla., as a collaboration to accelerate cancer research discoveries that can translate to more effective clinical care. Using TCC, ORIEN has created a collaborative, “rapid-learning” environment that will share de-identified patient data to hasten the development of targeted treatments and more quickly match eligible patients to clinical trials. The network currently includes 18 cancer centers.

For more information on TCC click here

Arm 2: Tissue Procurement Services (back to top)

The second arm of the BSSR provides prospectively procured tissue from surgical procedures to OSUCCC investigators who require pathology samples that have not been previously banked. The Department of Pathology Tissue Procurement Service (TPS) operates within the OSUWMC hospitals to facilitate research requiring the procurement of human tissues. All human tissue samples taken for research at OSUWMC hospitals must be coordinated through TPS. Samples are processed according to protocol.

Scott Scrape, MD - Director Scott.Scrape@osumc.edu

Scott Scrape, MD, is a Professor-Clinical in the Clinical Pathology Branch. He serves as the Director of Transfusion Medicine at OSUWMC. He earned his MD in 2004 and completed his residency in 2008 in Anatomic and Clinical Pathology at the University of Arkansas for Medical Sciences. He also completed a fellowship in Transfusion Medicine at the University of Arkansas for Medical Sciences in 2009.

Tissue Procurement Services

N343 Doan Hall
Phone: 614-366-1579

Marlene Parker, PA, ASCP
Clinical Lab Manager
Surgical Pathology and Tissue Procurement Services

CCCT D578
(614) 685-4829
Marlene.Parker@osumc.edu

For more information on TSP click here

Arm 3: BSSR Biorepository (back to top)

BSSR Biorepository Manager: Jason Bacher, BA

Arm 3 of the BSSR provides biospecimen processing and banking services to investigators for IRB-approved and grant-funded projects, including but not limited to SPOREs, P01s, R01s and statewide Pelotonia-funded initiatives. Specimen processing techniques include, but are not limited to, serum and plasma, DNA extractio

n from peripheral blood, frozen tissue, saliva, buccal swabs and immortalized lymphoblast or fibroblast cell lines. Specimens are maintained in locked freezers that are in a secure building that can only be accessed by employee keycards. All information pertaining to the sample processing and storage as well as related clinical information is maintained in a secure web-based database. Each sample receives a unique identifier. Information such as sample type,

date sample collected, sample concentration, and storage location is entered into the database. The Biorepository is monitored by the Rees Scientific Environmental monitoring system to ensure proper environmental and storage conditions 24 hours a day. In the event of a power failure, the biorepository is connected to a diesel-powered generator that will keep the freezers operating until full power is restored. To date, the BSSR Biorepository has banked over 140,000 specimens.

For more information on the Biorepository click here